With full treatment,

• you can see lasting results for up to 18 months with Restylane,
• up to 12 months in the cheeks, up to 6 months in the back of the hands and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft 
• and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.

Restylane Lyft: In a clinical trial involving 150 subjects, blinded evaluators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months. In a clinical trial involving 89 treated subjects, blinded evaluators observed that 86% of subjects* treated with Restylane Lyft showed an improvement in volume of the back of the hands at 3 months, and 76% of subjects* showed an improvement at 6 months. Improvement was defined as subjects with a Merz Hand Grading Scale (MHGS) score of ≥1 grade from baseline by the blinded evaluator's live assessment.

*n=85 subjects treated.

Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.

Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.

*The duration of effectiveness of Restylane for the correction of nasolabial folds (NLFs) was evaluated in a randomized, evaluator-blinded multicenter study. Restylane was shown to have an overall duration of effectiveness of 18 months from baseline following retreatment at 4.5 or 9 months.